Bring UltraShear Technology nanoemulsions (UST‑Nano™) in‑house.
The BaroShear NE-5 Gen 2 drives your macro/micro emulsion through a patented, self-throttling Nano-Gap™ valve at up to 30,000 psi. Final droplets range from above 200 nm down to about 20 nm, set by your formulation, the pressure, and the number of passes.
First-production systems are limited. Apply to reserve a build slot. Applying is free, there is no obligation, and Ric Schumacher replies personally within one business day.
Own it outright, no lease. Financing available for qualified non-cannabis buyers, with no payments for the first four months. Ask Ric for terms
Product rendering
US 11,156,295 and US 10,823,159: the valve and the processing system
ElSohly et al. 2023, Med Cannabis Cannabinoids
Smejkal et al. 2021, Molecules
Pressure BioSciences, Inc. · Canton, Massachusetts
The limit is often not the molecule. It is the droplet.
Many valuable active ingredients, such as cannabinoids, carotenoids, CoQ10 and fat-soluble vitamins, are lipophilic. How they are presented to the gut, the skin, or a beverage depends heavily on the size and uniformity of the oil droplets that carry them.
Estimated oral bioavailability of cannabidiol (CBD) in fasted humans.
Perucca & Bialer, CNS Drugs, 2020
Interfacial area
For a fixed oil volume, taking droplets from 1 µm to 50 nm multiplies the oil–water interface twentyfold, which speeds lipolysis and micellar solubilization.
Optical clarity
Well below the wavelength of light, scattering falls with the sixth power of diameter. Halve the droplet and scattering drops about 64-fold, so the emulsion turns clear.
Stability
A narrow size distribution slows Ostwald ripening. Below 100 nm, Brownian motion outweighs gravity, so creaming slows dramatically.
135 nm to 46 nm in six passes.
Starting emulsion shown pre-processing, and then after each pass through the BaroShear NE-5. Mean droplet diameter falls steeply over the first few passes and then begins to level off, and the sample clarifies as it does. Pass count is the simplest lever you have.
Mean droplet diameter of six UST-process passes on the BaroShear™ NE-5.
Your formulation, your numbers.
Apply for a build slot, or ask whether feasibility processing of your own formulation is possible.
One patented valve. Three levers you control.
A coarse starting emulsion is pressurized to as much as 30,000 psi and forced through an annular valve whose gap is in the nanometer range. The valve is self-throttling: its clearance adapts dynamically, which is designed to resist the clogging and erosion that limit fixed-orifice valves.
Start with your macro/micro emulsion
Your active in its oil phase, with your surfactant system, blended to a coarse starting emulsion.
Up to 30,000 psi, continuous flow
The fluid accelerates through the nanometer-range gap and meets intense, uniform shear, at up to 0.8 L/min per pass.
Tune pressure, formulation, and passes
Repeat passes to step droplet size down. Each product is tuned to its own desired target size and clarity.
| Method | Typical limitation | Consequence |
|---|---|---|
| Rotor–stator | Limited energy density | Struggles to reach the sub-200 nm range |
| Ultrasonic | Uneven energy field; scale-up difficulty | Broad distributions that favour Ostwald ripening |
| Fixed-orifice high-pressure | Narrow fixed orifice | Reaches the nanoscale, but erodes and clogs |
| UltraShear (patented, self-throttling Nano-Gap™ valve) | Pressure, formulation, and pass count are tuned per product | Achieves reproducible, homogeneous 20 to 200+ nm droplets, resulting in Designer Nanoemulsions |
Qualitative comparison for orientation, from the white paper. Patents US 11,156,295 and US 10,823,159.
BaroShear NE‑5 Gen2, specified.
A medium-sized, floor-model high pressure homogenizer built to create oil-in-water nanoemulsions on the patented BaroShear UST platform for R&D, pilot production, and manufacturing runs.
| Parameter | Specification |
|---|---|
| Working pressure | 10,000–30,000 psi; optimum setting 30,000 psi |
| Maximum flow | 0.8 L/min per pass |
| Droplet range | From above 200 nm down to about 20 nm, depending on formulation, parameters, and number of passes |
| Tanks | 2 × 10 L jacketed, pre- and post-process |
| Temperature control | Stainless-steel heat-exchange coils; chiller included |
| Power | 5 HP; 208–240 V AC, 1-phase, 50/60 Hz, 30 A |
| Size and weight | 48 × 30 × 30 in; ≤ 350 lb (estimated) |
| Enclosure | Stainless steel, IP-54 or better |
| Operating space | 8 × 8 ft minimum |
| Warranty | 1 year on non-consumable parts, travel and labor |
Source: Pressure BioSciences specification sheet, 21 September 2026. Site infrastructure (DI and potable water, drainage, filtration cassettes, consumables) is provided by the customer; we advise on specifications.
How long will your batch take?
Arithmetic from the maximum rated flow of 0.8 L/min per pass. Actual flow depends on pressure and formulation; set-up, cleaning and changeover are excluded.
General arrangement drawing: front, side, rear and top views. Illustrative; not for dimensional reference.
The first in-vivo data, with its limits.
ElSohly, Shahzadi and Gul (2023) dosed a ≈60 nm UltraShear CBD nanoemulsion to rats and compared bioavailability with a dose-adjusted IV reference. The formulation was made on the BaroShear Mini benchtop system.
F = parent CBD; A = CBD plus 7-OH-CBD and 7-COOH-CBD as CBD-equivalents. Oral n = 4, IV n = 3. Open-access paper (PMC10629855). The study was partly funded by Pressure BioSciences.
What a reviewer will ask
- Very small groups: four rats orally and three by IV.
- No matched oral control in the same study, so the size of any advantage over a conventional formulation is not yet measured.
- The IV arm used a different vehicle, so route and vehicle are confounded.
- Rat data do not translate directly to people. Matched-control and human PK studies are the next step.
The whole story in ten short chapters.
From the absorption barrier to the valve, the first in-vivo data and what a reviewer will ask, through to scaling on the NE-5. Pick a chapter or play straight through. Captions are on.
Where teams evaluate UltraShear.
The physics applies to any lipophilic active ingredient carried in an oil phase. Each product should be judged on its own data; these are candidate applications, not performance claims.
Pharmaceutical R&D
Poorly water-soluble APIs and lipid-based oral or topical systems that need small, narrow droplets and sterile filtration where possible.
Nutraceuticals
Oil-soluble active ingredients where higher bioavailability is the goal, such as carotenoids, CoQ10, curcumin, omega-3, astaxanthin, and vitamins A, D, E and K in clear, stable liquid formats with less surfactant.
Cannabinoids and botanicals
CBD, THC, minor cannabinoids, and botanical extracts for water-compatible beverages, sprays, and drops designed for fast onset.
Food and beverage
Flavor oils, colors, and fortificants in transparent beverages, processed cold.
Cosmetics and personal care
Oils, vitamins, and botanical active ingredients in light, clear serums and sprays.
Agrochemical and industrial
Oil-soluble actives and adjuvants in concentrates that stay stable on dilution.
The first consumer product made with UltraShear.
Shear Sciences' Super Antioxidant Oil Complex Oral NanoSpray carries astaxanthin, coenzyme Q10, curcumin and vitamin D3 in sea buckthorn, buah merah, pequi, MCT and acai berry oils. Nanoemulsified with UltraShear and packaged preservative-free.
Shown as an example of UltraShear in commercial production. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
What could a smaller droplet be worth to you?
Teams bring nanoemulsions in-house to test a lower dose of an expensive active, to make clear and stable water-compatible products, or to measure absorption against their current format. Tell us your project and size the opportunity with your own numbers.
- Droplet size and PDI after each pass
- Clarity and 0.22 µm filtration
- Shelf stability at your storage conditions
- Absorption, in your own study against your current format
If your formulation works at a lower dose…
Illustrative arithmetic on your own assumptions, not a prediction. Whether a lower dose gives the same result in your product has to be shown in your own testing; this page makes no therapeutic or health claims. Equipment, processing and surfactant costs are not included.
We help you formulate, prove it and market it.
Build slots go to teams we can help succeed, which is why we ask you to apply. Every application gets a conversation with Ric Schumacher and a Pressure BioSciences scientist.
Formulation help
Our scientists work with you on surfactant choice, oil loading, and pass strategy, drawing on what the data show for similar systems.
Ask for formulation help →Feasibility processing
It is sometimes possible to process your formulation and report particle size, PDI and appearance by pass. A reasonable charge may apply.
Request feasibility →Made with UltraShear
Eligible customers may co-brand their products with the UltraShear mark to set them apart on the shelf, subject to Pressure BioSciences' approval and a written agreement.
Ask about co-branding →Research and teaching labs
Universities, institutes and teaching labs are welcome to apply for a build slot, with the same formulation support and financing options as industry teams.
Apply as a research lab →Questions now? Ask Olivia, our UltraShear Expert.
Olivia is Ric Schumacher's SI assistant (an AI, not a person). She answers from Shear Sciences' published material, notes your project, and sets up your call with Ric. Chat or talk, any time.
Four steps to your own NE‑5.
Most teams decide in four steps. It starts with a short application and a 20-minute discussion, with no obligation.
Your active, oil phase, current process, and target format, with a Pressure BioSciences scientist.
Surfactant, loading, and pass strategy, and what the data show for similar systems.
It is sometimes possible to process your formulation and report particle size, PDI and appearance by pass. There may be a reasonable charge for this service.
Your purchase terms and financing options for the BaroShear NE-5 in writing, with the possibility of a partnership on a study.
The Bioavailability Gap.
Why so much of an oil-based active never reaches the body, and what droplet size has to do with it. The full story in about four minutes, and the brief in under two.
From Health On The Water, a podcast on wellness, the water and the science of absorption. The episodes are general discussion; this page makes no therapeutic or health claims.
Read the science.
The peer-reviewed papers are open to everyone. The white paper unlocks as soon as you send the short form.
From Droplet to Dose
Mechanism, process data, the rat study and its limits, and NE-5 specifications with throughput planning.
Free. Unlocks here when you send the form.
ElSohly et al. 2023
Absorption and bioavailability of a novel UltraShear nanoemulsion of cannabidiol in rats. Med Cannabis Cannabinoids 6:148–159.
Smejkal et al. 2021
Astaxanthin nanoemulsions produced through a self-throttling nanometer-range annular orifice valve. Molecules 26:2856.
Reserve your build slot.
Tell us about your formulation and your plans. Applying is free and there is no obligation.
- Ric Schumacher or one of our other scientists reviews your application and replies personally within one business day to book your 20-minute call.
- A discovery call with a Pressure BioSciences scientist on your active, oil phase, process and target format.
- Your purchase terms and financing options in writing, with feasibility processing of your formulation where possible.
Thank you. Your application is in.
Ric Schumacher will reply within one business day. Your white paper is unlocked below.
If you see no confirmation from us within a day, please press send again or email Ric directly.
The UltraShear Science Brief.
For formulation scientists and the teams that scale their products.
- New process data and application notes
- Formulation tips: surfactants, loading, and pass strategy
- The latest peer-reviewed work on nanoemulsions and bioavailability
What is the BaroShear NE-5 Gen 2?
A medium-sized, floor-model ultra-high-pressure homogenizer for oil-in-water nanoemulsions on the patented UltraShear Technology (UST) platform. It runs at 10,000–30,000 psi with continuous flow of up to 0.8 L/min per pass, for R&D, pilot and manufacturing runs.
What droplet sizes can it reach?
Final droplets range from above 200 nm down to about 20 nm, set by your formulation, the pressure, and the number of passes. In Pressure BioSciences' own data, one emulsion went from 135 nm to 46 nm in six passes on the NE-5.
Why are build slots limited?
The first production run has a limited number of systems, so Pressure BioSciences allocates them by application, after a conversation with each team about its formulation and site. Applying is free and carries no obligation.
How do I get pricing and availability?
Send the short application form. Ric Schumacher or one of our scientists replies within one business day and provides pricing, availability and purchase terms in writing.
Do I own the machine, or lease it?
You own it outright as your own capital asset, together with a right to use the UltraShear patents under Pressure BioSciences' license terms. There is no lease and nothing to hand back. Ric explains the full purchase and license terms in writing after you apply.
Is financing available?
Yes, for qualified non-cannabis buyers, with no payments for the first four months. Financing requires bank approval and a refundable security deposit. Ask Ric for terms; he provides them in writing after you apply.
Can cannabis companies buy or finance the NE-5?
Cannabis and psychotropic producers can buy the NE-5, but bank financing through Pressure BioSciences is not available for that use. For cannabinoids and psychotropics the machine is for your own production only, with no contract processing for others, and it stays in the state where it is installed.
Can I co-brand my product with UltraShear?
Eligible customers may label products "Made with UltraShear", subject to Pressure BioSciences' approval and a written agreement. We also help with formulation so the product earns the mark. Tick "Co-branding" when you apply.
Can you process my formulation first?
It is sometimes possible to process your formulation and report particle size, PDI and appearance by pass. There may be a reasonable charge for this service.
What does my site need?
208–240 V AC, 1-phase, 50/60 Hz, 30 A power and at least 8 × 8 ft of operating space. DI and potable water, drainage, filtration cassettes and consumables are provided by the customer; we advise on specifications.
What happens after the warranty year?
Year one is covered. From year two an optional extended service contract is available for one, two or three years; Ric includes the terms with your purchase terms.
What is included, and what is the warranty?
Two 10 L jacketed tanks, stainless-steel heat-exchange coils with a chiller, and a stainless-steel enclosure rated IP-54 or better. The warranty is one year on non-consumable parts, travel and labor.
What is the evidence on bioavailability?
One peer-reviewed rat study (ElSohly et al., 2023) with small groups and no matched oral control. Matched-control and human PK studies are the next step. This page makes no therapeutic or health claims.